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Association of Fatal Overdose Notification Letters With Prescription of Benzodiazepines Secondary Analysis of a Randomized Clinical Trial

In a randomized clinical trial (NCT02790476), Doctor et al1 studied the effect of notifying physicians of a patient’s fatal drug overdose within 12 months of a scheduled drug prescription for that patient. The physicians received an injunction to prescribe safely from their county's medical examiner. This intervention was associated with reductions in overall, high-dose, and new opioid prescriptions. In this article, we evaluate the association of these letters with benzodiazepine prescribing, which also contribute to drug deaths.

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